The Registry is a centralized data structure that Windows programs, including the Windows itself, use to store configuration data.
Every software installs specific registry files into the registry called registry keys, those files help the operating system on how to deal with this particular software… hence the software meant by a program or a Windows driver.
You can do that BUT it is highly not recommended as the Registry files are so critical and any simple mistake by editing a registry key or deleting one without being 100% sure about what are you doing would cause a Windows crash or instability.
As stated by Microsoft,
If your computer does not restart, the registry hives may be corrupted. The error messages may vary. They can include any of the following:
Reference: Microsoft Corporation
There are many reasons behind that and sometimes it is difficult to find the cause of registry corruption, but I am listing below some possible causes that you may try to fix:
Note: A registry corruption might occur via a virus or spyware injection, so better to be sure that you operating system is clean of viruses and trojans.
To know how to scan and clean your computer form viruses and harmful injection you may visit How to clean my PC from viruses tutorial, and to read more about the viruses types visit the Types of Viruses, Spyware and Hijackers page.
There are many ways to do so, most of them are hard for average users to implement and its recommended to ask a professional technician for that in case of the below instructions did not solve the problem, but in most cases you as a normal user can implement some of the below methods:
1. Restore the computer to a previous state before registry corruption occurred (Learn how to use the Windows Restore)
Note: if you cannot log in to your computer, you need to restore the Windows from the Recovery Console, I will post a new tutorial for how to do that as this will make this article so long.
2. Run the chkdsk /r command-line command on the disk that contains the registry hive files (normally C: drive). This command helps verify that the area of the disk that contains the registry hive files is not involved in the problem.
Note: To do that you have to :

The operation will occur after your restart.
3. Update all your Windows drivers. (to learn more click on How to deal with Windows Drivers)
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Nice & useful topics on computer.
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Thanks Faisal
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thanx firas for all usefull informations
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Most Welcome Hind..
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